2007 Computer-Aided Detection System Applied to Full-Field Digital Mammograms Authors: Yang SK, Moon WK, Cho N, et al. Published: Radiology 2007; 241; 104-111 OBJECTIVE: To retrospectively evaluate the sensitivity of the performance of a computer-aided detection system applied to full field digital mammograms for detection of breast cancers in a screening group, with histologic findings as the reference standard. RESULTS: The R2 CAD system correctly marked 99 (96.1%) of 103 breast cancers. The R2 CAD system marked all 44 breast cancers that manifested as microcalcifications only, all 23 breast cancers that manifested as a mass with microcalcifications, and 32 (89%) of 36 lesions that appeared as a mass only. The sensitivity of the CAD system in the fatty breast group was 95% (59 of 62) and in the dense breast group was 98% (40 of 41) (P .537). The CAD system correctly marked all 31 lesions of ductal carcinoma in situ (DCIS), all 22 lesions of invasive ductal carcinoma with DCIS, the single invasive lobular carcinoma lesion, and 45 (92%) of 49 lesions of invasive ductal carcinoma. On normal mammograms, the mean number of false-positive marks per patient was 1.80 (range, 0–10 marks; median, 1 mark)." Effect of Computer-Aided Detection on Independent Double Reading of Paired Screen-Film and Full-Field Digital Screening Mammograms Authors: Per Skaane, Ashwini Kshirsagar, Sandra Stapleton, Kari Young, Ronald A. Castellino Published: AJR 2007; 188: 377 - 384. OBJECTIVE: To evaluate the performance and potential contribution of computer-aided detection (CAD) to independent double reading of paired screen-film and full-field digital (FFDM) screening mammograms. RESULTS: For FFDM, CAD sensitivity was 95% compared with 64% for double reading (p = 0.006), and for screen-film mammography, CAD sensitivity was 85% compared with 77% for prospective double reading (p = 0.57) of radiographically visible lesions in baseline mammograms. CAD correctly marked five (13%) of 39 cancers on screen-film mammography and 14 (36%) of 39 cancers on FFDM not detected at prospective independent double reading. CAD showed the potential to increase the cancer detection rate for FFDM and for screen-film mammography in breast cancer screening performed with independent double reading. This modified abstract is displayed and reprinted here with permission from the American Roentgen Ray Society.