2005 Impact of CAD in a Regional Screening Mammography Program Authors: Cupples TE, Cunningham JE, Reynolds JC Published: AJR 2005; 185:944-950. OBJECTIVE:A prospective study to assess the effect of computer-aided detection (CAD) on screening outcomes in a regional mammography program. CONCLUSION:Overall, the study found that detection rates for breast cancer increased by 16.1% with CAD input. Of importance, the detection rates for small, invasive breast cancers (1.0 cm or less) increased by 164% and the mean age at screening detection of cancer with CAD was 5.3 years younger than in those for whom CAD was not used. This modified abstract is displayed and reprinted here with permission from the American Roentgen Ray Society.   Computer Aided Detection (CAD) With Screening Mammography in a University Hospital Setting. Authors: Birdwell R, Bandodkar P, Ikeda D Published: Radiology 2005; 236: 451-457. OBJECTIVE: A prospective clinical study of 8,682 screening mammograms designed to assess the effect of computer-aided detection (CAD) on screening mammogram interpretation in an academic medical center to determine if the outcome is different than that previously reported for community practices. RESULTS: CAD-prompted recalls contributed 8% (73/960) of total recalled findings and 7% (2/29) of cancers detected. Of 29 cancers, 17 (59%) manifested as masses and 12 (41%) were microcalcifications. Ten (34%) cancers were ductal carcinoma in situ, and the remaining cancers had an invasive component. Both cancers found with CAD manifested as masses, and both were invasive ductal carcinoma. CONCLUSION: Prospective clinical use of CAD in a university hospital setting resulted in a 7.4% increase (from 27 to 29) in cancers detected. Both cancers found with CAD manifested as masses, and both were invasive ductal carcinoma.